Drug interactions
Dasatinib + Ezogabine
Severity: Major
Dasatinib and Ezogabine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ezogabine and dasatinib can prolong the QT interval. Combined use may increase the risk of serious ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Dasatinib and Ezogabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Ezogabine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Obtain a baseline ECG and monitor the QTc during treatment, and correct hypokalemia and hypomagnesemia. Consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ezogabine
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ezogabine?
MediHelp rates the interaction as major. Dasatinib and Ezogabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both ezogabine and dasatinib can prolong the QT interval. Combined use may increase the risk of serious ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Dasatinib and Ezogabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during treatment, and correct hypokalemia and hypomagnesemia. Consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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