Drug interactions
Dasatinib + Fluticasone-salmeterol
Severity: Moderate
Dasatinib and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib has been associated with QT prolongation, and salmeterol can add to QTc and heart rate effects. The combination may modestly increase arrhythmia risk, particularly with electrolyte disturbances.
What this interaction means in plain words
Dasatinib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QTc prolongation from dasatinib and beta-2 agonist effects of salmeterol.
What to do
Check potassium and magnesium and consider a baseline ECG with follow-up in patients with cardiac risk factors. Use standard salmeterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Dasatinib and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib has been associated with QT prolongation, and salmeterol can add to QTc and heart rate effects. The combination may modestly increase arrhythmia risk, particularly with electrolyte disturbances.
How serious is the interaction between Dasatinib and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and consider a baseline ECG with follow-up in patients with cardiac risk factors. Use standard salmeterol doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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