Drug interactions
Dasatinib + Foscarnet
Severity: Major
Dasatinib and Foscarnet: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib and foscarnet each can prolong QT, and foscarnet may lower calcium and magnesium. Together the risk of clinically significant arrhythmia is increased.
What this interaction means in plain words
Dasatinib and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Foscarnet belongs to Anti Virals.
Why it happens
Additive QT prolongation with electrolyte disturbance from foscarnet.
What to do
Check ECG and electrolytes before and during treatment and correct hypokalemia, hypomagnesemia and hypocalcemia. Consider an alternative if QTc rises substantially.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Foscarnet?
MediHelp rates the interaction as major. Dasatinib and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib and foscarnet each can prolong QT, and foscarnet may lower calcium and magnesium. Together the risk of clinically significant arrhythmia is increased.
How serious is the interaction between Dasatinib and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before and during treatment and correct hypokalemia, hypomagnesemia and hypocalcemia. Consider an alternative if QTc rises substantially.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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