Drug interactions
Dasatinib + Givinostat
Severity: Major
Dasatinib and Givinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat and dasatinib can each prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia. Givinostat labeling advises caution with other QT-prolonging drugs.
What this interaction means in plain words
Dasatinib and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Givinostat belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination if possible. If it is unavoidable, obtain ECGs at initiation and during treatment, and withhold givinostat if the QTc exceeds 500 ms or rises more than 60 ms from baseline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Dasatinib with Givinostat?
MediHelp rates the interaction as major. Dasatinib and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat and dasatinib can each prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia. Givinostat labeling advises caution with other QT-prolonging drugs.
How serious is the interaction between Dasatinib and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is unavoidable, obtain ECGs at initiation and during treatment, and withhold givinostat if the QTc exceeds 500 ms or rises more than 60 ms from baseline.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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