Drug interactions
Dasatinib + Hydroxyurea
Severity: Moderate
Dasatinib and Hydroxyurea: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, so concurrent use can deepen neutropenia, thrombocytopenia and anemia. This matters because dasatinib is itself associated with cytopenias and bleeding.
What this interaction means in plain words
Dasatinib and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts frequently, and adjust the doses or interrupt treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Dasatinib with Hydroxyurea?
MediHelp rates the interaction as moderate. Dasatinib and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, so concurrent use can deepen neutropenia, thrombocytopenia and anemia. This matters because dasatinib is itself associated with cytopenias and bleeding.
How serious is the interaction between Dasatinib and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, and adjust the doses or interrupt treatment for significant cytopenias.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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