Drug interactions
Dasatinib + Istradefylline
Severity: Moderate
Dasatinib and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses istradefylline inhibits CYP3A4 and can increase dasatinib exposure. This may increase dasatinib-related adverse effects.
What this interaction means in plain words
Dasatinib and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline.
What to do
Keep istradefylline at 20 mg/day if possible and monitor for dasatinib toxicity, adjusting the dasatinib dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Dasatinib with Istradefylline?
MediHelp rates the interaction as moderate. Dasatinib and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses istradefylline inhibits CYP3A4 and can increase dasatinib exposure. This may increase dasatinib-related adverse effects.
How serious is the interaction between Dasatinib and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg/day if possible and monitor for dasatinib toxicity, adjusting the dasatinib dose if needed.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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