Drug interactions
Dasatinib + Ivosidenib
Severity: Major
Dasatinib and Ivosidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and ivosidenib induces CYP3A4, which can lower dasatinib exposure. The result may be QT-related arrhythmia and reduced dasatinib efficacy.
What this interaction means in plain words
Dasatinib and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 induction by ivosidenib, lowering dasatinib levels.
What to do
Avoid the combination or choose alternatives. If coadministration is unavoidable, monitor the ECG and electrolytes and assess the response to dasatinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Dasatinib with Ivosidenib?
MediHelp rates the interaction as major. Dasatinib and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, and ivosidenib induces CYP3A4, which can lower dasatinib exposure. The result may be QT-related arrhythmia and reduced dasatinib efficacy.
How serious is the interaction between Dasatinib and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or choose alternatives. If coadministration is unavoidable, monitor the ECG and electrolytes and assess the response to dasatinib.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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