Drug interactions
Dasatinib + Larotrectinib
Severity: Minor
Dasatinib and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is metabolized by CYP3A4 and may be a weak inhibitor of it, so an effect on dasatinib exposure is possible but not well characterized. Increased dasatinib levels could worsen myelosuppression, fluid retention and QT prolongation.
What this interaction means in plain words
Dasatinib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reduces dasatinib metabolism; this is not well established.
What to do
Monitor blood counts and for fluid retention during co-therapy. Consider a dasatinib dose reduction if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Dasatinib with Larotrectinib?
MediHelp rates the interaction as minor. Dasatinib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is metabolized by CYP3A4 and may be a weak inhibitor of it, so an effect on dasatinib exposure is possible but not well characterized. Increased dasatinib levels could worsen myelosuppression, fluid retention and QT prolongation.
How serious is the interaction between Dasatinib and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for fluid retention during co-therapy. Consider a dasatinib dose reduction if toxicity occurs.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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