Drug interactions
Dasatinib + Lefamulin
Severity: Major
Dasatinib and Lefamulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a moderate CYP3A4 inhibitor and can raise dasatinib exposure, and both drugs can prolong the QT interval. This increases the risk of arrhythmia and dasatinib toxicity such as myelosuppression and fluid retention.
What this interaction means in plain words
Dasatinib and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Lefamulin belongs to Anti Bacterial.
Why it happens
Lefamulin inhibits CYP3A4, increasing dasatinib levels, with additive QT prolongation.
What to do
Use an alternative antibiotic where possible. If used, monitor ECG, electrolytes and blood counts, and consider a dasatinib dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Dasatinib with Lefamulin?
MediHelp rates the interaction as major. Dasatinib and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin is a moderate CYP3A4 inhibitor and can raise dasatinib exposure, and both drugs can prolong the QT interval. This increases the risk of arrhythmia and dasatinib toxicity such as myelosuppression and fluid retention.
How serious is the interaction between Dasatinib and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If used, monitor ECG, electrolytes and blood counts, and consider a dasatinib dose reduction.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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