Drug interactions
Dasatinib + Metformin-pioglitazone
Severity: Minor
Dasatinib and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib weakly inhibits CYP3A4, which could modestly raise pioglitazone exposure. Pioglitazone is cleared mainly by CYP2C8 with a smaller CYP3A4 contribution, so a clinically meaningful change is unlikely.
What this interaction means in plain words
Dasatinib and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by dasatinib may slightly reduce pioglitazone metabolism.
What to do
No dose change is needed; monitor glycemic control and signs of fluid retention as part of routine pioglitazone care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Dasatinib and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib weakly inhibits CYP3A4, which could modestly raise pioglitazone exposure. Pioglitazone is cleared mainly by CYP2C8 with a smaller CYP3A4 contribution, so a clinically meaningful change is unlikely.
How serious is the interaction between Dasatinib and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor glycemic control and signs of fluid retention as part of routine pioglitazone care.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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