Drug interactions
Dasatinib + Metformin-repaglinide
Severity: Minor
Dasatinib and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak time-dependent CYP3A4 inhibitor and may modestly raise exposure to CYP3A4 substrates such as repaglinide. Dasatinib can also affect glucose levels, with hypoglycemia and hyperglycemia reported.
What this interaction means in plain words
Dasatinib and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Metformin-repaglinide belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4 metabolism of repaglinide.
What to do
Monitor blood glucose during dasatinib therapy and reduce repaglinide dosage if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Metformin-repaglinide?
MediHelp rates the interaction as minor. Dasatinib and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak time-dependent CYP3A4 inhibitor and may modestly raise exposure to CYP3A4 substrates such as repaglinide. Dasatinib can also affect glucose levels, with hypoglycemia and hyperglycemia reported.
How serious is the interaction between Dasatinib and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during dasatinib therapy and reduce repaglinide dosage if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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