Drug interactions
Dasatinib + Methadone
Severity: Moderate
Dasatinib and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, which adds to methadone's arrhythmia risk. Dasatinib is also a weak CYP3A4 inhibitor and may modestly raise methadone levels.
What this interaction means in plain words
Dasatinib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with weak CYP3A4 inhibition by dasatinib.
What to do
Obtain a baseline ECG and monitor the QTc, and correct potassium and magnesium. Watch for sedation or respiratory depression from rising methadone levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Methadone?
MediHelp rates the interaction as moderate. Dasatinib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib can prolong the QT interval, which adds to methadone's arrhythmia risk. Dasatinib is also a weak CYP3A4 inhibitor and may modestly raise methadone levels.
How serious is the interaction between Dasatinib and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc, and correct potassium and magnesium. Watch for sedation or respiratory depression from rising methadone levels.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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