Drug interactions
Dasatinib + Miconazole
Severity: Moderate
Dasatinib and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a CYP3A4 substrate, and strong inhibitors raise its exposure substantially. Miconazole is a CYP3A4 inhibitor with limited systemic exposure from vaginal use. Higher dasatinib levels may increase myelosuppression, fluid retention and QT prolongation.
What this interaction means in plain words
Dasatinib and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, reducing dasatinib clearance.
What to do
Monitor blood counts, fluid status and QT interval if miconazole is used. Prefer a topical agent with minimal absorption or a non-azole alternative when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Miconazole?
MediHelp rates the interaction as moderate. Dasatinib and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a CYP3A4 substrate, and strong inhibitors raise its exposure substantially. Miconazole is a CYP3A4 inhibitor with limited systemic exposure from vaginal use. Higher dasatinib levels may increase myelosuppression, fluid retention and QT prolongation.
How serious is the interaction between Dasatinib and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, fluid status and QT interval if miconazole is used. Prefer a topical agent with minimal absorption or a non-azole alternative when feasible.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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