Drug interactions
Dasatinib + Nelfinavir
Severity: Major
Dasatinib and Nelfinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir is a strong CYP3A4 inhibitor and can raise dasatinib levels, increasing the risk of myelosuppression, effusions and QT prolongation. Dasatinib may slightly raise nelfinavir levels.
What this interaction means in plain words
Dasatinib and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated dasatinib metabolism by nelfinavir.
What to do
Prefer an alternative antiretroviral; if necessary, reduce the dasatinib dose and monitor closely for toxicity and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Dasatinib with Nelfinavir?
MediHelp rates the interaction as major. Dasatinib and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir is a strong CYP3A4 inhibitor and can raise dasatinib levels, increasing the risk of myelosuppression, effusions and QT prolongation. Dasatinib may slightly raise nelfinavir levels.
How serious is the interaction between Dasatinib and Nelfinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiretroviral; if necessary, reduce the dasatinib dose and monitor closely for toxicity and QTc.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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