Drug interactions
Dasatinib + Nifedipine
Severity: Minor
Dasatinib and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a CYP3A4 substrate, and nifedipine is only a weak inhibitor, so any rise in exposure is expected to be small. Dasatinib can cause fluid retention, which may overlap with nifedipine-related edema.
What this interaction means in plain words
Dasatinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine reducing dasatinib metabolism.
What to do
No dose adjustment is usually needed. Monitor for dasatinib toxicity such as fluid retention and myelosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Nifedipine?
MediHelp rates the interaction as minor. Dasatinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a CYP3A4 substrate, and nifedipine is only a weak inhibitor, so any rise in exposure is expected to be small. Dasatinib can cause fluid retention, which may overlap with nifedipine-related edema.
How serious is the interaction between Dasatinib and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for dasatinib toxicity such as fluid retention and myelosuppression.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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