Drug interactions
Dasatinib + Palifermin
Severity: Moderate
Dasatinib and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates growth of epithelial cells, and when it was given close to cytotoxic chemotherapy, mucositis became more severe and lasted longer. Dasatinib is an oral kinase inhibitor taken continuously, so a strict 24-hour window is hard to apply, and any benefit of palifermin is unestablished with this drug.
What this interaction means in plain words
Dasatinib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-driven epithelial proliferation may increase the sensitivity of mucosal tissue to antineoplastic agents; the mechanism with dasatinib specifically is not established.
What to do
Avoid palifermin around dasatinib therapy unless there is a clear indication, and monitor the oral mucosa if used. Palifermin is labeled for use outside the 24 hours surrounding cytotoxic chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Palifermin
Frequently asked questions
Can I take Dasatinib with Palifermin?
MediHelp rates the interaction as moderate. Dasatinib and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates growth of epithelial cells, and when it was given close to cytotoxic chemotherapy, mucositis became more severe and lasted longer. Dasatinib is an oral kinase inhibitor taken continuously, so a strict 24-hour window is hard to apply, and any benefit of palifermin is unestablished with this drug.
How serious is the interaction between Dasatinib and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid palifermin around dasatinib therapy unless there is a clear indication, and monitor the oral mucosa if used. Palifermin is labeled for use outside the 24 hours surrounding cytotoxic chemotherapy.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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