Drug interactions
Dasatinib + Paroxetine
Severity: Moderate
Dasatinib and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, and paroxetine adds a small potential effect. The combined risk of arrhythmia is modest but higher with electrolyte disturbance or heart disease.
What this interaction means in plain words
Dasatinib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Paroxetine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor the QT interval periodically during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Paroxetine?
MediHelp rates the interaction as moderate. Dasatinib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib can prolong the QT interval, and paroxetine adds a small potential effect. The combined risk of arrhythmia is modest but higher with electrolyte disturbance or heart disease.
How serious is the interaction between Dasatinib and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor the QT interval periodically during co-therapy.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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