Drug interactions
Dasatinib + Pioglitazone
Severity: Minor
Dasatinib and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor, which could slightly raise pioglitazone concentrations. Because CYP2C8 is the main route of pioglitazone metabolism, the effect is likely minimal.
What this interaction means in plain words
Dasatinib and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Pioglitazone belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated pioglitazone metabolism.
What to do
No routine adjustment is needed. Watch for edema and hypoglycemia if pioglitazone effects appear increased.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Pioglitazone?
MediHelp rates the interaction as minor. Dasatinib and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor, which could slightly raise pioglitazone concentrations. Because CYP2C8 is the main route of pioglitazone metabolism, the effect is likely minimal.
How serious is the interaction between Dasatinib and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for edema and hypoglycemia if pioglitazone effects appear increased.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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