Drug interactions
Dasatinib + Ponesimod
Severity: Moderate
Dasatinib and Ponesimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod slows heart rate and dasatinib can prolong the QT interval, so the combination may raise the risk of bradycardia-related arrhythmia. Evidence for a direct interaction is limited and mostly based on the pharmacodynamic profiles of each drug.
What this interaction means in plain words
Dasatinib and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Ponesimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac conduction: ponesimod-induced bradycardia with dasatinib QT prolongation.
What to do
Obtain a baseline ECG before starting ponesimod and monitor heart rate and QTc during co-treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Dasatinib with Ponesimod?
MediHelp rates the interaction as moderate. Dasatinib and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponesimod slows heart rate and dasatinib can prolong the QT interval, so the combination may raise the risk of bradycardia-related arrhythmia. Evidence for a direct interaction is limited and mostly based on the pharmacodynamic profiles of each drug.
How serious is the interaction between Dasatinib and Ponesimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ponesimod and monitor heart rate and QTc during co-treatment.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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