Drug interactions
Dasatinib + Primidone
Severity: Major
Dasatinib and Primidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolised to phenobarbital and acts as a CYP3A4 inducer, which can lower dasatinib exposure. Reduced drug levels may compromise disease control.
What this interaction means in plain words
Dasatinib and Primidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Primidone belongs to Central Nervous System.
Why it happens
CYP3A4 induction (via primidone and its metabolite phenobarbital) increases dasatinib clearance.
What to do
Prefer a non-inducing antiepileptic. If combined, consider increasing the dasatinib dose and monitor disease response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Dasatinib with Primidone?
MediHelp rates the interaction as major. Dasatinib and Primidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Primidone is metabolised to phenobarbital and acts as a CYP3A4 inducer, which can lower dasatinib exposure. Reduced drug levels may compromise disease control.
How serious is the interaction between Dasatinib and Primidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiepileptic. If combined, consider increasing the dasatinib dose and monitor disease response closely.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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