Drug interactions
Dasatinib + Rufinamide
Severity: Minor
Dasatinib and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may modestly lower dasatinib concentrations. The clinical effect is probably small but could matter in patients with a marginal response.
What this interaction means in plain words
Dasatinib and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases dasatinib metabolism.
What to do
No dose change is usually needed. Monitor disease response and consider a dasatinib dose adjustment if response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Dasatinib with Rufinamide?
MediHelp rates the interaction as minor. Dasatinib and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and may modestly lower dasatinib concentrations. The clinical effect is probably small but could matter in patients with a marginal response.
How serious is the interaction between Dasatinib and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor disease response and consider a dasatinib dose adjustment if response is lost.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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