Drug interactions
Dasatinib + Selpercatinib
Severity: Moderate
Dasatinib and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and selpercatinib is also a weak CYP3A4 inhibitor. The combination may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Dasatinib and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible minor increase in dasatinib exposure through CYP3A4 inhibition.
What to do
Monitor ECG and electrolytes at baseline and during treatment. Reduce the dose or interrupt therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Dasatinib with Selpercatinib?
MediHelp rates the interaction as moderate. Dasatinib and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and selpercatinib is also a weak CYP3A4 inhibitor. The combination may increase the risk of ventricular arrhythmias.
How serious is the interaction between Dasatinib and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during treatment. Reduce the dose or interrupt therapy if QTc becomes markedly prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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