Drug interactions
Dasatinib + Sunitinib
Severity: Moderate
Dasatinib and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and sunitinib is a CYP3A4 substrate whose levels may rise with dasatinib. The combination may increase arrhythmia risk and sunitinib toxicity.
What this interaction means in plain words
Dasatinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation plus weak CYP3A4 inhibition by dasatinib.
What to do
Monitor ECG and electrolytes, and watch for sunitinib toxicity such as hypertension and cytopenias. Reduce the sunitinib dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Dasatinib with Sunitinib?
MediHelp rates the interaction as moderate. Dasatinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs prolong the QT interval, and sunitinib is a CYP3A4 substrate whose levels may rise with dasatinib. The combination may increase arrhythmia risk and sunitinib toxicity.
How serious is the interaction between Dasatinib and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for sunitinib toxicity such as hypertension and cytopenias. Reduce the sunitinib dose if adverse effects arise.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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