Drug interactions
Dasatinib + Tamoxifen
Severity: Minor
Dasatinib and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and could modestly reduce tamoxifen N-demethylation. The effect on overall anti-estrogen activity is expected to be small. Both drugs can also affect QT interval.
What this interaction means in plain words
Dasatinib and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Tamoxifen belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by dasatinib slightly reduces tamoxifen conversion to N-desmethyltamoxifen; additive QT effects are possible.
What to do
No routine dose adjustment is required; consider ECG and electrolyte monitoring in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Tamoxifen?
MediHelp rates the interaction as minor. Dasatinib and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and could modestly reduce tamoxifen N-demethylation. The effect on overall anti-estrogen activity is expected to be small. Both drugs can also affect QT interval.
How serious is the interaction between Dasatinib and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is required; consider ECG and electrolyte monitoring in patients with QT risk factors.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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