Drug interactions
Dasatinib + Tolterodine
Severity: Moderate
Dasatinib and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may slightly raise tolterodine concentrations. Both drugs have some QT prolongation potential, so the combination may add to this risk.
What this interaction means in plain words
Dasatinib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Tolterodine belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition by dasatinib plus additive QT-prolonging effects.
What to do
Monitor the ECG and electrolytes in patients with QT risk factors, and watch for anticholinergic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Tolterodine?
MediHelp rates the interaction as moderate. Dasatinib and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak CYP3A4 inhibitor and may slightly raise tolterodine concentrations. Both drugs have some QT prolongation potential, so the combination may add to this risk.
How serious is the interaction between Dasatinib and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes in patients with QT risk factors, and watch for anticholinergic adverse effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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