Drug interactions
Dasatinib + Trastuzumab
Severity: Moderate
Dasatinib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause myelosuppression or increase infection risk, and trastuzumab raises neutropenia rates when combined with myelosuppressive chemotherapy. Combined use may therefore add to hematologic toxicity, although no direct pharmacokinetic interaction is established.
What this interaction means in plain words
Dasatinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic hematologic toxicity; no pharmacokinetic mechanism is established.
What to do
Monitor complete blood counts regularly and watch for signs of infection or febrile neutropenia. Hold or reduce dasatinib per labeling if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Dasatinib with Trastuzumab?
MediHelp rates the interaction as moderate. Dasatinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause myelosuppression or increase infection risk, and trastuzumab raises neutropenia rates when combined with myelosuppressive chemotherapy. Combined use may therefore add to hematologic toxicity, although no direct pharmacokinetic interaction is established.
How serious is the interaction between Dasatinib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for signs of infection or febrile neutropenia. Hold or reduce dasatinib per labeling if severe neutropenia occurs.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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