Drug interactions
Dasiglucagon + Propranolol
Severity: Moderate
Dasiglucagon and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta blockade may blunt the catecholamine-mediated effects of dasiglucagon, and the combination can produce a transient rise in pulse and blood pressure. Hypoglycemia rescue is generally still effective but the hemodynamic response can be altered.
What this interaction means in plain words
Dasiglucagon and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasiglucagon belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic opposition: propranolol blocks beta-adrenergic effects of catecholamines released after dasiglucagon, with unopposed alpha stimulation possible.
What to do
Monitor blood glucose, heart rate and blood pressure after dasiglucagon is given to a patient taking propranolol. Give additional glucose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Dasiglucagon
- Atenolol + Dasiglucagon Moderate
- Dasiglucagon + Esmolol Moderate
- Dasiglucagon + Timolol Moderate
- Dasiglucagon + Warfarin Moderate
- Atenolol-chlorthalidone + Dasiglucagon Minor
- Betaxolol + Dasiglucagon Minor
Frequently asked questions
Can I take Dasiglucagon with Propranolol?
MediHelp rates the interaction as moderate. Dasiglucagon and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta blockade may blunt the catecholamine-mediated effects of dasiglucagon, and the combination can produce a transient rise in pulse and blood pressure. Hypoglycemia rescue is generally still effective but the hemodynamic response can be altered.
How serious is the interaction between Dasiglucagon and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, heart rate and blood pressure after dasiglucagon is given to a patient taking propranolol. Give additional glucose if the response is inadequate.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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