Drug interactions
Dasiglucagon + Esmolol
Severity: Moderate
Dasiglucagon and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasiglucagon, like glucagon, can transiently raise heart rate and blood pressure through catecholamine release, and beta-blockade may alter this response. Beta-blockers may also mask hypoglycemia symptoms and delay recovery.
What this interaction means in plain words
Dasiglucagon and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasiglucagon belongs to Endocrine; Esmolol belongs to Cardiovascular.
Why it happens
Glucagon-induced catecholamine release produces effects that are modified by beta-adrenergic blockade, with unopposed alpha stimulation possible.
What to do
Monitor blood pressure, pulse and blood glucose after dasiglucagon administration in patients on esmolol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Dasiglucagon
- Atenolol + Dasiglucagon Moderate
- Dasiglucagon + Propranolol Moderate
- Dasiglucagon + Timolol Moderate
- Dasiglucagon + Warfarin Moderate
- Atenolol-chlorthalidone + Dasiglucagon Minor
- Betaxolol + Dasiglucagon Minor
Frequently asked questions
Can I take Dasiglucagon with Esmolol?
MediHelp rates the interaction as moderate. Dasiglucagon and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasiglucagon, like glucagon, can transiently raise heart rate and blood pressure through catecholamine release, and beta-blockade may alter this response. Beta-blockers may also mask hypoglycemia symptoms and delay recovery.
How serious is the interaction between Dasiglucagon and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, pulse and blood glucose after dasiglucagon administration in patients on esmolol.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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