Drug interactions
Dasiglucagon + Timolol
Severity: Moderate
Dasiglucagon and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasiglucagon may transiently raise heart rate and blood pressure, and beta-blockers may blunt the catecholamine-mediated part of its glycemic response. Glucagon-type agents given to patients on nonselective beta-blockers can produce unopposed alpha effects with hypertension and reflex bradycardia.
What this interaction means in plain words
Dasiglucagon and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasiglucagon belongs to Endocrine; Timolol belongs to Cardiovascular.
Why it happens
Beta-blockade opposes catecholamine release stimulated by dasiglucagon, with a possible transient pressor effect.
What to do
Monitor blood pressure, heart rate and blood glucose after dasiglucagon administration in patients on timolol, and be ready to give additional glucose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Dasiglucagon
- Atenolol + Dasiglucagon Moderate
- Dasiglucagon + Esmolol Moderate
- Dasiglucagon + Propranolol Moderate
- Dasiglucagon + Warfarin Moderate
- Atenolol-chlorthalidone + Dasiglucagon Minor
- Betaxolol + Dasiglucagon Minor
Frequently asked questions
Can I take Dasiglucagon with Timolol?
MediHelp rates the interaction as moderate. Dasiglucagon and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasiglucagon may transiently raise heart rate and blood pressure, and beta-blockers may blunt the catecholamine-mediated part of its glycemic response. Glucagon-type agents given to patients on nonselective beta-blockers can produce unopposed alpha effects with hypertension and reflex bradycardia.
How serious is the interaction between Dasiglucagon and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and blood glucose after dasiglucagon administration in patients on timolol, and be ready to give additional glucose if the response is inadequate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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