Drug interactions
Dasiglucagon + Warfarin
Severity: Moderate
Dasiglucagon and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon-class agents such as dasiglucagon may enhance the anticoagulant effect of warfarin. This can raise the INR and increase bleeding risk. The effect is typically seen with repeated or sustained use.
What this interaction means in plain words
Dasiglucagon and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasiglucagon belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
The mechanism is not well established; glucagon may reduce synthesis or increase catabolism of vitamin K-dependent clotting factors.
What to do
Check the INR more frequently when dasiglucagon is used repeatedly in a patient on warfarin. Reduce the warfarin dose if the INR rises above target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasiglucagon
- Atenolol + Dasiglucagon Moderate
- Dasiglucagon + Esmolol Moderate
- Dasiglucagon + Propranolol Moderate
- Dasiglucagon + Timolol Moderate
- Atenolol-chlorthalidone + Dasiglucagon Minor
- Betaxolol + Dasiglucagon Minor
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Dasiglucagon with Warfarin?
MediHelp rates the interaction as moderate. Dasiglucagon and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon-class agents such as dasiglucagon may enhance the anticoagulant effect of warfarin. This can raise the INR and increase bleeding risk. The effect is typically seen with repeated or sustained use.
How serious is the interaction between Dasiglucagon and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the INR more frequently when dasiglucagon is used repeatedly in a patient on warfarin. Reduce the warfarin dose if the INR rises above target.
What other medicines interact with Dasiglucagon?
MediHelp also lists interactions of Dasiglucagon with, for example, Atenolol, Esmolol, Propranolol. The full list is on the Dasiglucagon page.
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