Drug interactions
Daunorubicin + Fostemsavir
Severity: Moderate
Daunorubicin and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active moiety temsavir inhibits BCRP in vitro, which could raise exposure to BCRP substrates. Increased daunorubicin exposure could intensify hematologic and cardiac toxicity, though clinical data are lacking.
What this interaction means in plain words
Daunorubicin and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Fostemsavir belongs to Anti Virals.
Why it happens
Temsavir inhibition of BCRP efflux transport may increase daunorubicin exposure.
What to do
Monitor blood counts and cardiac status during overlap, and reduce the daunorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Daunorubicin with Fostemsavir?
MediHelp rates the interaction as moderate. Daunorubicin and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active moiety temsavir inhibits BCRP in vitro, which could raise exposure to BCRP substrates. Increased daunorubicin exposure could intensify hematologic and cardiac toxicity, though clinical data are lacking.
How serious is the interaction between Daunorubicin and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status during overlap, and reduce the daunorubicin dose if toxicity develops.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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