Drug interactions
Daunorubicin + Leniolisib
Severity: Moderate
Daunorubicin and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may increase systemic exposure to BCRP substrates such as daunorubicin. This could worsen myelosuppression and other anthracycline toxicities.
What this interaction means in plain words
Daunorubicin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Leniolisib belongs to Miscellaneous.
Why it happens
BCRP inhibition reduces daunorubicin efflux and raises its exposure.
What to do
Monitor blood counts and cardiac function closely during combined use. Reduce the daunorubicin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Daunorubicin with Leniolisib?
MediHelp rates the interaction as moderate. Daunorubicin and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP and may increase systemic exposure to BCRP substrates such as daunorubicin. This could worsen myelosuppression and other anthracycline toxicities.
How serious is the interaction between Daunorubicin and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely during combined use. Reduce the daunorubicin dose if toxicity appears.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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