Drug interactions
Daunorubicin + Lonafarnib
Severity: Moderate
Daunorubicin and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and may modestly increase exposure to daunorubicin, a P-gp substrate. Because daunorubicin has a narrow therapeutic index, even small increases may matter.
What this interaction means in plain words
Daunorubicin and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibition of P-glycoprotein efflux may raise daunorubicin concentrations.
What to do
Monitor blood counts, mucositis and cardiac function, and reduce the daunorubicin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Daunorubicin with Lonafarnib?
MediHelp rates the interaction as moderate. Daunorubicin and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a weak P-glycoprotein inhibitor and may modestly increase exposure to daunorubicin, a P-gp substrate. Because daunorubicin has a narrow therapeutic index, even small increases may matter.
How serious is the interaction between Daunorubicin and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, mucositis and cardiac function, and reduce the daunorubicin dose if adverse effects occur.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
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