Drug interactions
Daunorubicin + Nicardipine
Severity: Moderate
Daunorubicin and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can inhibit P-glycoprotein and may raise intracellular and systemic exposure to daunorubicin. This could in theory increase myelosuppression and cardiotoxicity, although the clinical significance is not well established.
What this interaction means in plain words
Daunorubicin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of daunorubicin by nicardipine.
What to do
Monitor blood counts and cardiac function during concurrent use. Be alert for enhanced anthracycline toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Frequently asked questions
Can I take Daunorubicin with Nicardipine?
MediHelp rates the interaction as moderate. Daunorubicin and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine can inhibit P-glycoprotein and may raise intracellular and systemic exposure to daunorubicin. This could in theory increase myelosuppression and cardiotoxicity, although the clinical significance is not well established.
How serious is the interaction between Daunorubicin and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function during concurrent use. Be alert for enhanced anthracycline toxicity.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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