Drug interactions
Daunorubicin + Regorafenib
Severity: Moderate
Daunorubicin and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP efflux and could raise systemic exposure to daunorubicin. This could increase myelosuppression and cardiotoxicity, although clinical data are limited.
What this interaction means in plain words
Daunorubicin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Possible inhibition of BCRP (ABCG2) transport by regorafenib, reducing daunorubicin efflux.
What to do
Monitor blood counts and cardiac function, including cumulative anthracycline dose. Consider dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Daunorubicin with Regorafenib?
MediHelp rates the interaction as moderate. Daunorubicin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP efflux and could raise systemic exposure to daunorubicin. This could increase myelosuppression and cardiotoxicity, although clinical data are limited.
How serious is the interaction between Daunorubicin and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, including cumulative anthracycline dose. Consider dose reduction if toxicity emerges.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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