Drug interactions
Daunorubicin + Ritonavir
Severity: Moderate
Daunorubicin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits P-glycoprotein and CYP3A4 and may increase daunorubicin exposure. This may increase myelosuppression and cardiotoxicity.
What this interaction means in plain words
Daunorubicin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits P-gp efflux and metabolism of daunorubicin.
What to do
Monitor blood counts and cardiac function; reduce daunorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Daunorubicin with Ritonavir?
MediHelp rates the interaction as moderate. Daunorubicin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits P-glycoprotein and CYP3A4 and may increase daunorubicin exposure. This may increase myelosuppression and cardiotoxicity.
How serious is the interaction between Daunorubicin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function; reduce daunorubicin dose if toxicity develops.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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