Drug interactions
Daunorubicin + Vemurafenib
Severity: Moderate
Daunorubicin and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may raise systemic exposure to daunorubicin, which is a P-gp substrate. This could intensify myelosuppression, mucositis and cardiotoxicity. The clinical magnitude has not been well characterized.
What this interaction means in plain words
Daunorubicin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein efflux, reducing daunorubicin elimination and cellular efflux.
What to do
Monitor blood counts and signs of anthracycline toxicity closely. Consider reducing the daunorubicin dose if excessive toxicity occurs, and monitor cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Daunorubicin with Vemurafenib?
MediHelp rates the interaction as moderate. Daunorubicin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may raise systemic exposure to daunorubicin, which is a P-gp substrate. This could intensify myelosuppression, mucositis and cardiotoxicity. The clinical magnitude has not been well characterized.
How serious is the interaction between Daunorubicin and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of anthracycline toxicity closely. Consider reducing the daunorubicin dose if excessive toxicity occurs, and monitor cardiac function.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
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