Drug interactions
Debrisoquine + Trimipramine
Severity: Moderate
Debrisoquine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can block entry of guanethidine-like antihypertensives into adrenergic neurons. Debrisoquine may therefore lose its blood pressure lowering effect, leading to poor hypertension control.
What this interaction means in plain words
Debrisoquine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Trimipramine inhibits the neuronal amine uptake pump needed for debrisoquine to reach its site of action.
What to do
Monitor blood pressure when starting or stopping trimipramine. Consider a different antihypertensive class if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Debrisoquine with Trimipramine?
MediHelp rates the interaction as moderate. Debrisoquine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can block entry of guanethidine-like antihypertensives into adrenergic neurons. Debrisoquine may therefore lose its blood pressure lowering effect, leading to poor hypertension control.
How serious is the interaction between Debrisoquine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping trimipramine. Consider a different antihypertensive class if control is lost.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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