Drug interactions
Deferasirox + Duloxetine
Severity: Moderate
Deferasirox and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can inhibit CYP1A2, the main enzyme clearing duloxetine, so duloxetine exposure may rise. This can increase serotonergic and noradrenergic adverse effects such as nausea, dizziness, blood pressure elevation and agitation.
What this interaction means in plain words
Deferasirox and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Duloxetine belongs to Central Nervous System.
Why it happens
Deferasirox inhibits CYP1A2-mediated metabolism of duloxetine, reducing its clearance.
What to do
Monitor for duloxetine adverse effects and blood pressure when starting deferasirox. Reduce the duloxetine dose if tolerability problems appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Duloxetine?
MediHelp rates the interaction as moderate. Deferasirox and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can inhibit CYP1A2, the main enzyme clearing duloxetine, so duloxetine exposure may rise. This can increase serotonergic and noradrenergic adverse effects such as nausea, dizziness, blood pressure elevation and agitation.
How serious is the interaction between Deferasirox and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duloxetine adverse effects and blood pressure when starting deferasirox. Reduce the duloxetine dose if tolerability problems appear.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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