Drug interactions
Deferasirox + Estradiol
Severity: Moderate
Deferasirox and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower estradiol exposure, potentially reducing hormone therapy or contraceptive effectiveness. Effects on other CYP enzymes are also described.
What this interaction means in plain words
Deferasirox and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Estradiol belongs to Endocrine.
Why it happens
Deferasirox may induce CYP3A4-mediated estradiol metabolism.
What to do
Monitor symptom control or bleeding patterns, and use additional non-hormonal contraception if relying on estrogen for contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Estradiol?
MediHelp rates the interaction as moderate. Deferasirox and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and lower estradiol exposure, potentially reducing hormone therapy or contraceptive effectiveness. Effects on other CYP enzymes are also described.
How serious is the interaction between Deferasirox and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control or bleeding patterns, and use additional non-hormonal contraception if relying on estrogen for contraception.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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