Drug interactions
Deferasirox + Everolimus
Severity: Moderate
Deferasirox and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may induce CYP3A4 and lower everolimus exposure. Reduced exposure could diminish antitumor or immunosuppressive efficacy.
What this interaction means in plain words
Deferasirox and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Everolimus belongs to Oncology.
Why it happens
Possible weak CYP3A4 induction by deferasirox increasing everolimus metabolism.
What to do
Monitor clinical response and everolimus trough concentrations where available. Adjust the everolimus dose if levels are subtherapeutic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Everolimus?
MediHelp rates the interaction as moderate. Deferasirox and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may induce CYP3A4 and lower everolimus exposure. Reduced exposure could diminish antitumor or immunosuppressive efficacy.
How serious is the interaction between Deferasirox and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and everolimus trough concentrations where available. Adjust the everolimus dose if levels are subtherapeutic.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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