Drug interactions
Deferasirox + Iron sucrose
Severity: Moderate
Deferasirox and Iron sucrose: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron sucrose is given intravenously, so gut chelation is irrelevant, but deferasirox will still bind the iron delivered and oppose its therapeutic purpose. Using both is generally pointless unless iron status is carefully assessed.
What this interaction means in plain words
Deferasirox and Iron sucrose can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Iron sucrose belongs to Miscellaneous.
Why it happens
Deferasirox chelates iron and promotes its excretion, counteracting iron repletion.
What to do
Avoid giving iron sucrose to patients on deferasirox unless iron deficiency is confirmed. Monitor ferritin and transferrin saturation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron sucrose
- Dextrose 5% + Iron sucrose Contraindicated
- Deferiprone + Iron sucrose Moderate
- Deferoxamine + Iron sucrose Moderate
- Amlodipine-benazepril + Iron sucrose Minor
- Benazepril + Iron sucrose Minor
- Captopril-hydrochlorothiazide + Iron sucrose Minor
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Iron sucrose?
MediHelp rates the interaction as moderate. Deferasirox and Iron sucrose can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron sucrose is given intravenously, so gut chelation is irrelevant, but deferasirox will still bind the iron delivered and oppose its therapeutic purpose. Using both is generally pointless unless iron status is carefully assessed.
How serious is the interaction between Deferasirox and Iron sucrose?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving iron sucrose to patients on deferasirox unless iron deficiency is confirmed. Monitor ferritin and transferrin saturation.
What other medicines interact with Iron sucrose?
MediHelp also lists interactions of Iron sucrose with, for example, Dextrose 5%, Deferiprone, Deferoxamine. The full list is on the Iron sucrose page.
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