Drug interactions
dextrose 5% + iron sucrose
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Iron sucrose should not be diluted in dextrose 5%; it is only compatible with 0.9% sodium chloride. Mixing with D5W risks instability/precipitation and is not recommended per labeling.
Mechanism of action
Formulation/compatibility issue: iron sucrose is stable only in 0.9% sodium chloride; dilution in dextrose 5% can lead to instability or precipitation.
Clinical management
Avoid combining. Prepare iron sucrose in 0.9% sodium chloride only. If a D5W infusion is running, stop and flush the line or use a separate line with NS for dilution/administration.
Drug reference
References
- Venofer (iron sucrose injection) Prescribing Information — FDA Label
- Venofer - iron sucrose injection, USP — DailyMed
- Iron sucrose: Drug monograph—Administration and compatibility — Lexicomp
Frequently asked questions
Can I take dextrose 5% with iron sucrose?
The interaction is rated: Contraindicated. Iron sucrose should not be diluted in dextrose 5%; it is only compatible with 0.9% sodium chloride. Mixing with D5W risks instability/precipitation and is not recommended per labeling.
How serious is the interaction between dextrose 5% and iron sucrose?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dextrose 5% and iron sucrose managed?
Avoid combining. Prepare iron sucrose in 0.9% sodium chloride only. If a D5W infusion is running, stop and flush the line or use a separate line with NS for dilution/administration.
Why do dextrose 5% and iron sucrose interact?
Formulation/compatibility issue: iron sucrose is stable only in 0.9% sodium chloride; dilution in dextrose 5% can lead to instability or precipitation.
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