Drug interactions
Deferiprone + Iron sucrose
Severity: Moderate
Deferiprone and Iron sucrose: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron sucrose is given intravenously and delivers iron to the body, while deferiprone is an iron chelator intended to remove iron. Using them together is therapeutically opposed, and no gastrointestinal binding applies to the intravenous product.
What this interaction means in plain words
Deferiprone and Iron sucrose can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Iron sucrose belongs to Miscellaneous.
Why it happens
Pharmacodynamic opposition: deferiprone chelates the iron that iron sucrose supplies.
What to do
Avoid concurrent use unless there is a clear indication for each drug. Monitor ferritin, transferrin saturation and haemoglobin if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron sucrose
- Dextrose 5% + Iron sucrose Contraindicated
- Deferasirox + Iron sucrose Moderate
- Deferoxamine + Iron sucrose Moderate
- Amlodipine-benazepril + Iron sucrose Minor
- Benazepril + Iron sucrose Minor
- Captopril-hydrochlorothiazide + Iron sucrose Minor
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Iron sucrose?
MediHelp rates the interaction as moderate. Deferiprone and Iron sucrose can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron sucrose is given intravenously and delivers iron to the body, while deferiprone is an iron chelator intended to remove iron. Using them together is therapeutically opposed, and no gastrointestinal binding applies to the intravenous product.
How serious is the interaction between Deferiprone and Iron sucrose?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless there is a clear indication for each drug. Monitor ferritin, transferrin saturation and haemoglobin if both are used.
What other medicines interact with Iron sucrose?
MediHelp also lists interactions of Iron sucrose with, for example, Dextrose 5%, Deferasirox, Deferoxamine. The full list is on the Iron sucrose page.
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