Drug interactions
Deferasirox + Levoketoconazole
Severity: Minor
Deferasirox and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may weakly induce CYP3A4, which could lower levoketoconazole exposure. The clinical effect is modest and not well characterized, but reduced cortisol-lowering efficacy is conceivable.
What this interaction means in plain words
Deferasirox and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Levoketoconazole belongs to Endocrine.
Why it happens
Possible modest CYP3A4 induction by deferasirox increases metabolism of levoketoconazole.
What to do
Monitor urinary free cortisol and clinical response to levoketoconazole when deferasirox is started or stopped, and adjust the levoketoconazole dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deferasirox
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Deferasirox with Levoketoconazole?
MediHelp rates the interaction as minor. Deferasirox and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox may weakly induce CYP3A4, which could lower levoketoconazole exposure. The clinical effect is modest and not well characterized, but reduced cortisol-lowering efficacy is conceivable.
How serious is the interaction between Deferasirox and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary free cortisol and clinical response to levoketoconazole when deferasirox is started or stopped, and adjust the levoketoconazole dose if control is lost.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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