Drug interactions
Deferasirox + Lopinavir
Severity: Minor
Deferasirox and Lopinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may modestly lower exposure to CYP3A4 substrates such as lopinavir. The effect is not well quantified, but reduced antiviral exposure could compromise HIV suppression.
What this interaction means in plain words
Deferasirox and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Lopinavir belongs to Anti Virals.
Why it happens
Possible weak CYP3A4 induction by deferasirox increases lopinavir metabolism.
What to do
Monitor HIV viral load during coadministration; routine dose changes are not needed unless virologic response falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deferasirox
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Deferasirox with Lopinavir?
MediHelp rates the interaction as minor. Deferasirox and Lopinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox may modestly lower exposure to CYP3A4 substrates such as lopinavir. The effect is not well quantified, but reduced antiviral exposure could compromise HIV suppression.
How serious is the interaction between Deferasirox and Lopinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load during coadministration; routine dose changes are not needed unless virologic response falls.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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