Drug interactions
Deferasirox + Mirtazapine
Severity: Moderate
Deferasirox and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can inhibit CYP1A2 and may raise mirtazapine exposure, potentially increasing sedation and other adverse effects. The effect is expected to be modest because mirtazapine is metabolized by several pathways.
What this interaction means in plain words
Deferasirox and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Mirtazapine belongs to Central Nervous System.
Why it happens
Deferasirox inhibition of CYP1A2 reduces mirtazapine metabolism.
What to do
Monitor for increased sedation or adverse effects after starting deferasirox. Lower the mirtazapine dose if effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Mirtazapine?
MediHelp rates the interaction as moderate. Deferasirox and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can inhibit CYP1A2 and may raise mirtazapine exposure, potentially increasing sedation and other adverse effects. The effect is expected to be modest because mirtazapine is metabolized by several pathways.
How serious is the interaction between Deferasirox and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or adverse effects after starting deferasirox. Lower the mirtazapine dose if effects appear.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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