Drug interactions
Deferasirox + Temsirolimus
Severity: Moderate
Deferasirox and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 in some patients, which may lower exposure to temsirolimus and its active metabolite sirolimus. Reduced exposure could weaken antitumor activity.
What this interaction means in plain words
Deferasirox and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Deferasirox may weakly induce CYP3A4 and increase temsirolimus metabolism; the effect is not firmly established.
What to do
Monitor tumor response and consider whether temsirolimus efficacy is adequate. Reassess the combination if disease control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Temsirolimus?
MediHelp rates the interaction as moderate. Deferasirox and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 in some patients, which may lower exposure to temsirolimus and its active metabolite sirolimus. Reduced exposure could weaken antitumor activity.
How serious is the interaction between Deferasirox and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider whether temsirolimus efficacy is adequate. Reassess the combination if disease control worsens.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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