Drug interactions
Deferasirox + Zileuton
Severity: Moderate
Deferasirox and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2 and may raise exposure to CYP1A2 substrates such as zileuton. This could increase zileuton adverse effects, including liver enzyme elevation.
What this interaction means in plain words
Deferasirox and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Zileuton belongs to Respiratory.
Why it happens
Deferasirox inhibits CYP1A2, reducing zileuton metabolism.
What to do
Monitor liver enzymes and for zileuton adverse effects during combined use. Consider an alternative if hepatic enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Zileuton?
MediHelp rates the interaction as moderate. Deferasirox and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2 and may raise exposure to CYP1A2 substrates such as zileuton. This could increase zileuton adverse effects, including liver enzyme elevation.
How serious is the interaction between Deferasirox and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for zileuton adverse effects during combined use. Consider an alternative if hepatic enzymes rise.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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