Drug interactions
Deferiprone + Ferric citrate
Severity: Moderate
Deferiprone and Ferric citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral ferric citrate supplies iron that deferiprone binds in the gut, which can reduce deferiprone absorption. The two drugs also have opposing aims, since one lowers and the other raises iron stores.
What this interaction means in plain words
Deferiprone and Ferric citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Ferric citrate belongs to Miscellaneous.
Why it happens
Deferiprone chelates iron in the gastrointestinal lumen, lowering absorption of both agents.
What to do
Avoid the combination where possible; if needed, separate doses by at least 4 hours and monitor ferritin and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Ferric citrate
- Ciprofloxacin + Ferric citrate Moderate
- Doxycycline + Ferric citrate Moderate
- Ferric citrate + Gemifloxacin Moderate
- Ferric citrate + Levofloxacin Moderate
- Ferric citrate + Moxifloxacin Moderate
- Ferric citrate + Ofloxacin Moderate
Frequently asked questions
Can I take Deferiprone with Ferric citrate?
MediHelp rates the interaction as moderate. Deferiprone and Ferric citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral ferric citrate supplies iron that deferiprone binds in the gut, which can reduce deferiprone absorption. The two drugs also have opposing aims, since one lowers and the other raises iron stores.
How serious is the interaction between Deferiprone and Ferric citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, separate doses by at least 4 hours and monitor ferritin and phosphate.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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